Clinical Studies
If you’re considering ketamine treatment, it’s important to understand the research behind it. Below are two clinical studies that explore ketamine’s potential benefits, safety, and impact on symptoms like depression and chronic pain. These resources are provided to help you make an informed decision and learn more about how ketamine is being used in modern medicine.
Depression:
Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013;170(10):1134-1142. doi:10.1176/appi.ajp.2013.13030392
Shiroma PR, Thuras P, Wels J, Albott CS, Erbes C, Tye S, Lim KO. A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Transl Psychiatry. 2020;10(1):206. doi:10.1038/s41398-020-00897-0
Phillips JL, Norris S, Talbot J, et al. Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial. Am J Psychiatry. 2019;176(5):401-409. doi:10.1176/appi.ajp.2018.18070834
Anxiety:
[general efficacy for social anxiety]
Taylor JH, Landeros-Weisenberger A, Coughlin C, et al. Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial. Neuropsychopharmacology. 2018;43(2):325-333. doi:10.1038/npp.2017.194
[systematic review of 11 separate studies showing safety and efficacy of ketamine for anxiety]
Tully JL, Dahlén AD, Haggarty CJ, Schiöth HB, Brooks S. Ketamine treatment for refractory anxiety: A systematic review. Br J Clin Pharmacol. 2022 Oct;88(10):4412-4426. doi: 10.1111/bcp.15374. Epub 2022 May 20. PMID: 35510346; PMCID: PMC9540337.